Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

3.7K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
3.7K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

798
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
798
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.0K
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.9K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.9K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19-Associated Portal Vein Thrombosis Post-Cholecystitis.

The International journal of angiology : official publication of the International College of Angiology, Inc·2023
Same author

Hematologic Conditions: Leukocytosis and Leukemia.

FP essentials·2019
Same author

Hematologic Conditions: Common Hemoglobinopathies.

FP essentials·2019
Same author

Hematologic Conditions: Platelet Disorders.

FP essentials·2019
Same author

Diabetes in the elderly: Matching meds to needs.

The Journal of family practice·2018
Same author

Transient Ion-Pair Separations for Electrospray Mass Spectrometry.

Analytical chemistry·2016
Same journal

Skin Cancer: Management of Cutaneous Melanoma.

FP essentials·2026
Same journal

Skin Cancer: Management of Actinic Keratoses and Keratinocyte Carcinomas.

FP essentials·2026
Same journal

Skin Cancer: Diagnosis.

FP essentials·2026
Same journal

Skin Cancer: Screening and Prevention.

FP essentials·2026
Same journal

Skin Cancer.

FP essentials·2026
Same journal

Obesity Management: Surgical Interventions.

FP essentials·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K

Hematologic Conditions: Leukopenia.

Lily Lam1, James Mumford2, Barbara Keber1

  • 1Department of Family Medicine at Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY 11549.

FP Essentials
|October 16, 2019
PubMed
Summary
This summary is machine-generated.

Leukopenia, a reduction in white blood cells, often involves neutrophils. Neutropenia, defined by a low absolute neutrophil count (ANC), requires careful assessment and management to prevent serious infections like febrile neutropenia.

More Related Videos

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.9K
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

18.2K

Related Experiment Videos

Last Updated: Jan 5, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K
Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.9K
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

18.2K

Area of Science:

  • Hematology
  • Clinical Medicine

Background:

  • Leukopenia is a frequent outpatient finding, primarily due to reduced neutrophil counts.
  • Neutropenia is defined as an absolute neutrophil count (ANC) below 1,500/mcL.
  • Neutropenia can be transient or chronic, with chronic forms classified as extrinsic or intrinsic.

Purpose of the Study:

  • To outline the assessment and management strategies for patients presenting with neutropenia.
  • To highlight the risks associated with neutropenia, including severe bacterial infections and febrile neutropenia.

Main Methods:

  • Assessment guided by neutropenia severity, duration, and patient's clinical status.
  • Systematic risk assessment for febrile neutropenia in affected patients.

Main Results:

  • Neutropenia classification includes transient, chronic, extrinsic, and intrinsic types.
  • Intrinsic causes may involve impaired myeloid progenitor cell development in the bone marrow.

Conclusions:

  • Prompt assessment and risk stratification are crucial for managing neutropenia.
  • Treatment for febrile neutropenia involves antibiotics, while other cases focus on addressing the underlying cause.