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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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[The Role of microRNA in the Development of Ischemic Heart Disease]

N G Kukava1, R M Shkhnovich2, G Z Osmak3

  • 1Institute of Clinical Cardiology named after A.L. Myasnikov, National Cardiology Research Center.

Kardiologiia
|October 17, 2019
PubMed

Insights

MicroRNAs regulate key processes in atherosclerosis development. This review explores their role in coronary artery disease and potential as diagnostic markers.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Coronary artery disease (CAD) is a major global health burden, stemming from atherosclerosis.
  • Atherogenesis is a complex biological process involving cellular and molecular interactions.
  • MicroRNAs (miRNAs) have emerged as critical regulators in various pathophysiological pathways.

Purpose of the Study:

  • To review the involvement of specific microRNAs in the development of atherosclerosis.
  • To examine the role of microRNAs in the clinical manifestations of coronary artery disease.
  • To discuss the potential of microRNAs as diagnostic biomarkers for atherosclerosis and CAD.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies on microRNA function in atherogenesis.
  • Synthesis of data on microRNA involvement in CAD.

Main Results:

  • MicroRNAs are integral to the complex process of atherogenesis.
  • Specific microRNAs are implicated in the progression of atherosclerosis.
  • Evidence suggests microRNAs play a role in CAD's clinical outcomes.

Conclusions:

  • MicroRNAs are significant regulators in the pathogenesis of atherosclerosis.
  • MicroRNAs hold promise as potential diagnostic and prognostic biomarkers for CAD.
  • Further research is warranted to translate miRNA findings into clinical applications.

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