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Cutaneous reactions caused by nitrofurazone.
Serap Gunes Bilgili1, Goknur Ozaydin-Yavuz1, Ibrahim Halil Yavuz1
1Department of Dermatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.
Postepy Dermatologii I Alergologii
|October 17, 2019
Summary
Topical nitrofurazone can cause severe allergic contact dermatitis (ACD). Awareness and caution are crucial, especially on damaged skin, to prevent sensitization and adverse reactions.
Area of Science:
- Dermatology
- Allergology
- Pharmacovigilance
Background:
- Allergic contact dermatitis (ACD) is a type 4 hypersensitivity reaction.
- Topical nitrofurazone is a common antimicrobial agent known to cause ACD.
Purpose of the Study:
- Evaluate ACD cases linked to nitrofurazone use.
- Analyze clinical features and outcomes of nitrofurazone-induced ACD.
Main Methods:
- Retrospective analysis of 58 ACD cases due to nitrofurazone (2013-2017).
- Reviewed patient demographics, clinical presentations, lesion dissemination, and treatment.
Main Results:
- 58 cases identified; 79% male, 21% female.
- Common presentations included dyshidrosiform (45%) and excoriated papules/plaques (33%).
- Generalized dissemination occurred in 34 patients; mean hospitalization was 7 days.
Conclusions:
- Nitrofurazone can trigger widespread, severe ACD.
- Avoid application on damaged skin to prevent sensitization.
- Emphasize physician awareness of ACD risk and patient self-medication history.
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