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Updated: Jan 5, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Activation of HCAR2 by niacin: benefits beyond lipid lowering
1Department of Medicine, Division of Translational Medicine & Human Genetics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 11-143, Philadelphia, PA 19104, USA.
Abstract:
Niacin (nicotinic acid) is a potent lipid-lowering agent that has been used for prevention of coronary heart disease. Niacin activates the HCAR2 receptor found on adipocytes, macrophages and various immune cells throughout the body. Activation of the HCAR2 receptor by niacin results in beneficial anti-inflammatory effects that are independent of lipid lowering. This review summarizes the use of niacin in treatment of dyslipidemia, the pharmacogenetics of niacin response and the potential role of HCAR2 signaling in the treatment of a variety of inflammatory and metabolic diseases.
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