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Updated: Jan 5, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?
Mehmet Zahid Kocak1, Gulali Aktas1, Tuba T Duman1
1. Abant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Objective:
In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus.
Methods:
A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups.
Results:
Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups: 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group: 4.85 (1.92) mg/dl) (p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017).
Conclusion:
UA levels may be an important predictor of nephropathy in diabetic patients.
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