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Early Events in Coccidioidomycosis
Fariba M Donovan1,2, Lisa Shubitz3, Daniel Powell3
1Valley Fever Center for Excellence, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA faribadonovan@deptofmed.arizona.edu.
Clinical Microbiology Reviews
|October 18, 2019
Summary
This review focuses on early coccidioidomycosis (valley fever) and the pathogen-host interactions. It highlights research gaps and suggests future directions for understanding this fungal disease.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunology
Background:
- Coccidioidomycosis, or valley fever (VF), is caused by *Coccidioides* spp.
- Extensive research exists on established infections and complications of VF.
- Limited focus has been placed on the initial pathogen-host interactions in VF.
Purpose of the Study:
- To review existing literature on early coccidioidomycosis.
- To identify knowledge gaps concerning the initial stages of VF.
- To propose future research avenues for understanding early VF.
Main Methods:
- Literature review of studies on early coccidioidomycosis.
- Analysis of research focusing on pathogen-host interactions in the early disease stages.
- Synthesis of findings to identify research gaps and opportunities.
Main Results:
- Most VF literature addresses established infections and complications.
- Early pathogen-host interactions in VF are understudied.
- Gaps exist in understanding disease manifestation, progression, and resolution from the outset.
Conclusions:
- Further research into early coccidioidomycosis is crucial.
- Investigating initial host-pathogen interactions can provide insights into VF.
- Future studies should focus on the early stages of this invasive fungal disease.
Keywords:
Coccidioides researchcoccidioidomycosisearly coccidioidomycosisearly events in valley feverMore Related Videos
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