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Published on: March 30, 2014
Same-Day Associations Between Substance Use and Medication Nonadherence Among Persons Living with HIV
Susan E Ramsey1,2, Evan G Ames2, Julia Uber2
1The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Objectives:
To examine the same-day associations between substance use and objectively measured antiretroviral therapy (ART) nonadherence among persons living with HIV (PLWH).
Methods:
PLWH (N = 53) were given an electronic pill box (EPB), and their ART adherence was monitored for 14 days. During a follow-up interview, participants were asked about any alcohol or drug use that occurred during those same 14 days.
Results:
Daily heavy drinking (⩾5 drinks for males and ⩾4 drinks for females) was associated with a nearly five times greater likelihood of same-day ART nonadherence (OR = 4.90, 95% CI = 1.79-13.36, P = .002). Further, drug use was associated with a nearly two times greater likelihood of ART nonadherence on the same day (OR = 1.80, 95% CI = 1.14-2.85, P = .012).
Conclusions:
These results highlight the importance of continuing to pursue interventions to effectively address heavy drinking and drug use among PLWH in order to improve ART adherence.
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