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Updated: Jan 5, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
903
Acromegaly and papillary thyroid carcinoma: A case series
Maryam Heidarpour1, Hassan Rezvanian1, Ali Kachuei1
1Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Summary
Acromegaly patients face a higher risk of thyroid cancer due to excess insulin-like growth factor-1. This review examines available studies and case reports on this debated association.
Area of Science:
- Endocrinology
- Oncology
Background:
- Acromegaly is a rare endocrine disorder characterized by excess growth hormone.
- This condition is linked to an increased risk of various malignancies.
Observation:
- The association between acromegaly and thyroid cancer risk is debated, with limited large-scale studies.
- Chronic excess insulin-like growth factor-1 (IGF-1) may promote thyroid cell proliferation and inhibit apoptosis.
Findings:
- Existing literature suggests a potential five-fold increased risk of thyroid cancer in acromegaly patients.
- This review synthesizes current research and presents three illustrative case reports.
Implications:
- Further research is needed to clarify the precise risk and underlying mechanisms.
- Enhanced surveillance for thyroid abnormalities may be warranted in individuals with acromegaly.
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