Peppy: A virtual reality environment for exploring the principles of polypeptide structure

Area of Science:

• Biochemistry
• Educational Technology
• Structural Biology

Background:

• Understanding protein structure is crucial for biochemistry undergraduates.
• Traditional 2D teaching methods fail to convey the dynamic 3D nature of proteins.
• Existing research-oriented molecular modeling tools are complex for introductory learning.

Purpose of the Study:

• To develop and evaluate a virtual reality (VR) application, Peppy, for teaching protein secondary structure.
• To leverage game engine technology for an accessible and engaging learning experience.
• To improve undergraduate comprehension of protein structure principles.

Main Methods:

• Developed Peppy using the Unity video game physics engine.
• Focused on simplicity and core principles rather than high-fidelity molecular simulation.
• Deployed Peppy in undergraduate biochemistry courses for hands-on exploration.

Main Results:

• Peppy facilitates exploration of factors influencing polypeptide structure (hydrogen bonding, angles, sterics).
• The VR application provides a novel, dynamic, and enjoyable learning format.
• Initial deployment in courses yielded positive outcomes for student understanding.

Conclusions:

• Virtual reality, exemplified by Peppy, offers a powerful tool to enhance biochemistry education.
• Simplified models in VR can effectively teach complex structural concepts.
• Interactive VR applications can deepen student engagement and learning of protein structure.