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Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges

Ziyi Song1,2, Hao Yang3, Lei Zhou4

  • 1College of Animal Science and Technology, Guangxi University, Nanning 530004, China. Ziyi.Song@gxu.edu.cn.

International Journal of Molecular Sciences
|October 19, 2019
PubMed

Insights

Transcription factors MondoA and carbohydrate response element-binding protein (ChREBP) are key in glucose sensing. Their dysregulation contributes to type 2 diabetes (T2D), highlighting potential therapeutic targets for T2D treatment.

Area of Science:

  • Metabolic regulation
  • Molecular endocrinology
  • Diabetes research

Background:

  • Type 2 Diabetes (T2D) is a growing global health concern requiring new therapeutic strategies.
  • MondoA and carbohydrate response element-binding protein (ChREBP) are transcription factors crucial for glucose sensing and homeostasis.
  • Dysregulation of MondoA/ChREBP under nutrient overload contributes to insulin resistance and T2D pathogenesis.

Purpose of the Study:

  • To review recent advances in understanding MondoA/ChREBP.
  • To elucidate the roles of MondoA/ChREBP in T2D development.
  • To discuss therapeutic potential of targeting MondoA/ChREBP for T2D.

Main Methods:

  • Literature review of MondoA/ChREBP functions.
  • Analysis of MondoA/ChREBP roles in key metabolic organs (skeletal muscle, liver, adipose tissue, pancreas).
  • Discussion of drug targeting strategies for MondoA/ChREBP.

Main Results:

  • MondoA and ChREBP share similarities and differences in function.
  • MondoA/ChREBP play distinct roles in metabolic organs under physiological and pathological conditions relevant to T2D.
  • Evidence suggests MondoA/ChREBP are implicated in insulin resistance and T2D.

Conclusions:

  • MondoA/ChREBP are central to glucose metabolism and T2D development.
  • Targeting MondoA/ChREBP presents opportunities for novel anti-diabetic therapies.
  • Further research is needed to overcome challenges in developing MondoA/ChREBP-based treatments for T2D and its complications.
Keywords:
ChREBPMondoAadipose tissueglucoseinsulin resistancelivermetabolismpancreasskeletal muscletype 2 diabetes

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