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Mapping of gene encoding mouse placental alkaline phosphatase to chromosome 4
M Terao1, D Pravtcheva, F H Ruddle
1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Somatic Cell and Molecular Genetics
|March 1, 1988
Abstract:
The gene encoding the mouse placental alkaline phosphatase (ALP; orthophosphoric-monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1) is mapped to chromosome 4, based on Southern blot hybridization of the mouse cDNA with DNAs from mouse-Chinese hamster somatic cell hybrids. This assignment is consistent with the genetic analysis of the Akp-2 locus, which is responsible for the genetic variation of alkaline phosphatase enzyme in placenta as well as in liver, kidney, and bone.