Microglial Self-Recognition STINGs in A-T Neurodegeneration
Austin Ferro1, Carrie Sheeler1, Marija Cvetanovic2
1Department of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA.
Abstract:
Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.
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