Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.1K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

2.7K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K
The Bronchial Tree01:23

The Bronchial Tree

5.9K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
5.9K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic Insights into Intrauterine Growth Restriction and Its Role in Asthma Pathogenesis.

Journal of proteome research·2026
Same author

The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.

American journal of respiratory and critical care medicine·2026
Same author

Enhancing a diverse population: the American Thoracic Society Mentoring Program for Underrepresented in Medicine.

ATS scholar·2026
Same author

Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Increased Airway Smooth Muscle Shortening Is Associated With an Earlier Age of Sudden Unexpected Death in Infancy.

Journal of paediatrics and child health·2025
Same author

Intrauterine growth restriction promotes hypothalamic circadian dysregulation in adult mouse offspring.

Journal of developmental origins of health and disease·2025
Same journal

Beyond the 5th percentile: rethinking diagnostic thresholds in pulmonary function testing.

The European respiratory journal·2026
Same journal

A Transcriptomic Atlas of Chronic Lung Allograft Dysfunction.

The European respiratory journal·2026
Same journal

Risk of cancer and mortality in patients with interstitial lung diseases: Danish cohort study.

The European respiratory journal·2026
Same journal

Proposing a minimal important difference in NTproBNP in pulmonary arterial hypertension.

The European respiratory journal·2026
Same journal

Unlocking growth potential: Ivacaftor therapy and developmental gains in lung and height in a cohort study of children and young adults with cystic fibrosis.

The European respiratory journal·2026
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.8K

Fatty airways: implications for obstructive disease.

John G Elliot1,2, Graham M Donovan3, Kimberley C W Wang2,4

  • 1West Australian Sleep Disorders Research Institute, Dept of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia john.elliot@health.wa.gov.au.

The European Respiratory Journal
|October 19, 2019
PubMed
Summary
This summary is machine-generated.

Overweight individuals with asthma may experience more severe disease due to increased airway adipose tissue. This study found a link between body mass index (BMI) and airway fat accumulation, potentially worsening asthma pathology.

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.4K
Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.6K

Related Experiment Videos

Last Updated: Jan 5, 2026

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.8K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.4K
Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.6K

Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Immunology

Background:

  • Overweight and obese individuals with asthma often exhibit more severe disease.
  • Adipose tissue accumulation in the airway wall is a potential contributor to airway pathology in overweight asthmatics.

Purpose of the Study:

  • To investigate the relationship between airway wall adipose tissue and body mass index (BMI) in individuals with and without asthma.
  • To assess the association of airway adipose tissue with airway remodeling and inflammation.

Main Methods:

  • Post-mortem lung tissue sections from control subjects and asthma cases were analyzed.
  • Airway adipose tissue area and inflammatory cell counts (eosinophils, neutrophils) were quantified.
  • Relationships between adipose tissue, BMI, airway wall dimensions, and inflammation were statistically evaluated.

Main Results:

  • Adipose tissue was found in the outer walls of large airways, correlating positively with inflammatory cell counts in fatal asthma and control subjects.
  • Higher BMI was observed in non-fatal asthma cases.
  • Airway adipose tissue area showed a positive correlation with BMI, wall thickness, and inflammatory cell presence.

Conclusions:

  • Adipose tissue is present within the airway wall and its accumulation is related to BMI.
  • Increased airway adipose tissue in overweight individuals may play a role in the pathophysiology of asthma.
  • This finding highlights a potential mechanism linking obesity to severe asthma.