miR-190-5p in human diseases.

Area of Science:

• Molecular Biology
• Genetics
• Oncology

Background:

• MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression by targeting messenger RNAs.
• Dysregulation of miRNAs is increasingly recognized in various human diseases, particularly cancers.
• miR-190 has emerged as a significant miRNA implicated in multiple cancer types and related biological processes.

Purpose of the Study:

• To review and summarize the multifaceted roles of miR-190-5p in human diseases, with a specific emphasis on its involvement in human cancers.
• To classify the target genes regulated by miR-190-5p in the context of tumorigenesis and cancer progression.
• To explore the potential of miR-190-5p as a biomarker for cancer diagnosis and prognosis and as a therapeutic target.

Main Methods:

• Literature review and synthesis of existing research on miR-190-5p.
• Analysis of studies detailing miR-190-5p's involvement in cancer-related biological processes.
• Classification of identified miR-190-5p target genes involved in cancer.

Main Results:

• miR-190-5p is dysregulated in various human cancers.
• It plays critical roles in cancer proliferation, apoptosis, metastasis, and drug resistance by modulating specific target genes.
• Identified target genes provide insights into miR-190-5p's functions in tumorigenesis and progression.

Conclusions:

• miR-190-5p is a key player in human cancers, influencing critical oncogenic pathways.
• Its dysregulation suggests potential as a diagnostic and prognostic biomarker.
• Target gene analysis highlights miR-190-5p as a promising candidate for novel cancer therapeutics.