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Study design and protocol for evaluating the long-term prognosis of patients receiving his bundle pacing: A
Satoshi Yanagisawa1, Yasuya Inden2, Hiroyuki Kato3
1Department of Advanced Cardiovascular Therapeutics Nagoya University Graduate School of Medicine Nagoya Japan.
Insights
His bundle pacing (HBP) offers physiological ventricular activation. This study investigates HBP
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- His bundle pacing (HBP) is an emerging technique for physiological ventricular activation.
- Clear indications, efficacy, safety, and long-term outcomes of HBP remain under investigation.
Purpose of the Study:
- To evaluate the long-term prognosis of patients undergoing His bundle pacing.
- To assess changes in cardiac function following His bundle pacing implantation.
Main Methods:
- A multicenter observational prospective study was conducted in Japan.
- Included patients with atrioventricular block or conduction delay requiring ≥40% ventricular pacing.
- Follow-up extended to 3 years post-implantation, monitoring primary endpoints (all-cause death, HF hospitalization, CRT upgrade) and secondary endpoints (cardiac function).
Main Results:
- Results are currently under investigation and will be reported upon study completion.
Conclusions:
- This study aims to provide crucial evidence on the long-term prognosis and cardiac function changes in patients receiving His bundle pacing.
- Findings will aid in establishing evidence-based guidelines for HBP application and patient management.
Background:
His bundle pacing (HBP) is a recently developed pacing technique that can achieve an ideal physiological pattern of ventricular activation via stimulation of the native His-Purkinje system. Despite the widespread introduction of HBP in clinical practice, its appropriate indications are yet to be determined clearly. Moreover, the efficacy and safety of HBP and long-term prognosis of patients undergoing such are unknown.
Methods:
We conducted a multicenter observational prospective study in patients undergoing HBP in Japan. Patients with atrioventricular block or conduction delay and estimated ventricular pacing of ≥ 40% scheduled for HBP implantation are included. All patients are followed up until 3 years after the implantation. The primary endpoints are all-cause death, heart failure-related hospitalization, and upgrade to cardiac resynchronization therapy. The secondary endpoint is changes in cardiac function based on echocardiographic findings and laboratory data after the implantation.
Results:
The results are currently under investigation.
Conclusions:
This multicenter observational study evaluates the long-term prognosis and changes in cardiac function of patients undergoing HBP implantation in a clinical setting. Considering the large number of patients included, the cumulative results would be helpful in establishing evidence on HBP application in this area and consequently allow accurate management and treatment of patients undergoing HBP.
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