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Updated: Jan 5, 2026
An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
Published on: January 7, 2019
Comparative in vitro activity of bacteriophage endolysin HY-133 against Staphylococcus aureus attached to vascular
Evgeny A Idelevich1, Dennis Knaack1, Nyityasmono Tri Nugroho2
1Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Abstract:
Novel strategies are needed for combating Staphylococcus aureus biofilm in vascular graft infections. We investigated the in vitro activity of bacteriophage endolysin HY-133, daptomycin and rifampin against S. aureus attached to vascular graft surface. Daptomycin showed rapid bactericidal effect on surface-associated S. aureus, while the activity of HY-133 on graft surface-adherent cells was moderate and rifampin did not achieve bactericidal effect. Even in the highest concentrations, all antimicrobials used failed in a complete eradication of the surface-adherent bacteria.
