Related Experiment Video
Updated: Jan 5, 2026

11:44
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
21.0K
Inkjet-printed paper-based semiconducting substrates for surface-enhanced Raman spectroscopy
Leilei Lan1, Xiangyu Hou1, Yimeng Gao1
1School of Physics, Southeast University, Nanjing 211189, People's Republic of China.
Nanotechnology
|October 19, 2019
Summary
Researchers developed inkjet-printed, paper-based SERS substrates using MoO3-x nanosheets. These flexible, eco-friendly substrates offer simple, large-scale preparation for sensitive molecular detection.
Area of Science:
- Materials Science
- Analytical Chemistry
- Spectroscopy
Background:
- Surface-enhanced Raman spectroscopy (SERS) is a powerful molecular detection technique.
- Traditional SERS substrates face challenges in preparation complexity, eco-friendliness, cost, and flexibility.
- These limitations hinder the widespread application and development of SERS.
Purpose of the Study:
- To develop novel, simple, and eco-friendly SERS substrates.
- To create flexible and economically viable SERS platforms for molecular detection.
- To demonstrate the potential of inkjet-printed paper-based substrates for practical SERS applications.
Main Methods:
- Fabrication of paper-based semiconducting SERS substrates using inkjet printing with two-dimensional MoO3-x nanosheets ink.
- Utilizing the prepared substrates for sensitive detection of target molecules.
- Assessing the efficiency of sample collection via surface swabbing.
Main Results:
- Achieved a low detection limit of 10-7 M for rhodamine 6G.
- Demonstrated successful detection of crystal violet and malachite green on fish surfaces.
- Confirmed the simplicity, scalability, and flexibility of the inkjet-printed paper-based SERS substrates.
Conclusions:
- Inkjet-printed paper-based semiconducting SERS substrates offer a promising alternative to conventional methods.
- These substrates provide a simple, scalable, and flexible platform for efficient molecular detection.
- The developed technology opens new avenues for practical SERS applications in various fields.

