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Updated: Jan 5, 2026
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
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[Idiopathic diabetes]
I I Dedov1, K I Tabeeva1, T V Nikonova1
1Endocrinology Research Centre.
Problemy Endokrinologii
|October 20, 2019
Summary
Type 1 diabetes mellitus, a metabolic disease causing hyperglycemia, involves insulin secretion or action defects. It encompasses autoimmune and idiopathic forms, with the latter also known as type 1B or ketosis-prone diabetes.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Immunology
Context:
- Diabetes mellitus is defined by hyperglycemia due to insulin secretion or action defects.
- The World Health Organization (WHO) classification distinguishes four main types: type 1, type 2, gestational, and other types.
- Type 1 diabetes is characterized by pancreatic beta-cell destruction, leading to absolute insulin deficiency and ketoacidosis risk.
Purpose:
- To elaborate on the classification and characteristics of Type 1 diabetes mellitus.
- To differentiate between autoimmune and idiopathic forms of Type 1 diabetes.
- To introduce alternative nomenclature for idiopathic diabetes, such as Type 1B.
Summary:
- Type 1 diabetes mellitus results from pancreatic beta-cell destruction, causing absolute insulin deficiency and a propensity for ketoacidosis.
- While often autoimmune, Type 1 diabetes also includes idiopathic cases lacking autoimmune markers.
- Idiopathic diabetes, a subtype of Type 1, is also referred to as Type 1B, atypical, or ketosis-prone diabetes.
Impact:
- Clarifies the heterogeneity within Type 1 diabetes mellitus.
- Provides a basis for understanding distinct pathophysiological mechanisms.
- Enhances diagnostic clarity and research focus on different diabetes etiologies.
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