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Updated: Jan 5, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Idiopathic diabetes]
I I Dedov1, K I Tabeeva1, T V Nikonova1
1Endocrinology Research Centre.
Abstract:
Diabetes mellitus is a group of metabolic metabolic) diseases characterized by hyperglycemia that results from defects in insulin secretion, insulin action, or both of these factors (WHO, 1999). In the last etiological classification (WHO, 1999), 4 clinical types of diabetes mellitus are distinguished: type 1, type 2, other types (infections, genetic disorders, etc.) and gestational diabetes. Type 1 diabetes mellitus includes diseases caused by destruction (pancreatic β-cells, absolute insulin deficiency and a tendency to ketoacidosis. The vast majority of such cases have an autoimmune nature of the lesion, but there are groups of patients who do not show autoimmune markers Taking this into account, according to this classification, type 1 diabetes includes 2 types: autoimmune and idiopathic. Idiopathic diabetes is also called type 1B diabetes, atypical type 1 diabetes , ketosis-prone diabetes, tropical diabetes.
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