[Combined therapy for type 2 diabetes mellitus]

The development of diabetes is preceded by a number of stages of impaired carbohydrate tolerance. From the state of normal through the stage of impaired glucose tolerance, the development of type 2 diabetes mellitus, diabetes complications, the disease leads to death. With this understanding of the disease, the question arises: is it possible to prevent diabetes and its complications? With regard to type 2 diabetes, the answer is yes. Primary disease prevention involves exposure before the onset of the disease; the presence of a specific target, i.e., an etiological determinant; continued effect after discontinuation of therapy.The results of many studies have been published, which convincingly proved that drug and non-drug effects can prevent the transition of the stage of impaired glucose tolerance into diabetes mellitus.