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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Cell signaling stabilizes morphogenesis against noise.

Pascal F Hagolani1, Roland Zimm1,2, Miquel Marin-Riera3,4

  • 1Evo-devo Helsinki community, Centre of Excellence in Experimental and Computational Developmental Biology, Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland.

Development (Cambridge, England)
|October 20, 2019
PubMed
Summary
This summary is machine-generated.

Gene networks and cell signaling create complex embryonic morphologies. Compartmentalization via signaling is key for robust development, ensuring reliable patterns despite biological noise.

Keywords:
ComplexityDevelopmentEvolutionGene networksMorphogenesisRobustness

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Area of Science:

  • Developmental biology
  • Computational biology
  • Systems biology

Background:

  • Embryonic development relies on complex interactions between gene networks, cell signaling, and mechanical forces.
  • Coordinating these elements is crucial for generating robust and complex morphologies.

Purpose of the Study:

  • To investigate how gene networks and cell behaviors coordinate to produce robust embryonic morphologies.
  • To explore the role of cell signaling in achieving developmental robustness.

Main Methods:

  • Utilized EmbryoMaker, a computational model simulating animal development and morphology changes over time.
  • Generated numerous random gene networks and cell behavior configurations within the model.

Main Results:

  • Any gene network can generate complex morphologies if it activates cell behaviors broadly.
  • Robustness to noise requires gene networks with cell signaling that compartmentalizes the embryo.
  • Broad regulation of cell behaviors leads to complex but non-robust morphologies.

Conclusions:

  • Compartmentalization by cell signaling is essential for robust embryonic development.
  • This mechanism enhances robustness and is a common feature in animal development.
  • Findings support theories on the evolution of robustness through gene networks and signaling.