Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

1.3K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.3K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

640
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
640
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

564
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
564
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

700
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
700
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

717
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
717
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

1.1K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An <i>m</i>/<i>z</i>- and Intensity-Based HRMS Clustering Algorithm Targeted toward Single-Cell Metabolomics.

Journal of the American Society for Mass Spectrometry·2026
Same author

AV Node Ablation and Conduction System Pacing Versus Biventricular Pacing in Patients With AF and HF.

Pacing and clinical electrophysiology : PACE·2026
Same author

Ultrasonographic fetal sex determination in large domestic animals: a comparative, mechanistic, and field-oriented synthesis.

Frontiers in veterinary science·2026
Same author

Pregnancy-Associated Breast Cancer: A Trimester and Subtype Based Clinical Decision Framework for the Surgeon and Surgical Trainee.

Annals of surgical oncology·2026
Same author

Compliance With Foot Care Practices Among Patients With Diabetes Mellitus in Sudan.

International wound journal·2026
Same author

Male Dromedary Reproductive Emergencies: Clinical Presentation, Diagnosis, Management and Prognosis.

Animals : an open access journal from MDPI·2026

Related Experiment Video

Updated: Jan 5, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.2K

Post-POEM reflux: who's at risk?

Gabriel Arevalo1, Megan Sippey2, Luis A Martin-Del-Campo1

  • 1Department of Surgery, Case Western Reserve University/University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Lakeside Building, 7th Floor, Cleveland, OH, 44106, USA.

Surgical Endoscopy
|October 20, 2019
PubMed
Summary

Post-POEM reflux is common, with many patients remaining asymptomatic despite abnormal acid exposure. Higher preoperative Eckardt scores and esophagitis indicate increased risk for post-POEM reflux and esophagitis, necessitating close surveillance.

Keywords:
AchalasiaPOEMReflux

More Related Videos

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery
04:14

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

Published on: September 22, 2023

831
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.6K

Related Experiment Videos

Last Updated: Jan 5, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.2K
Author Spotlight: Recent Advancements in Reoperative Foregut Surgery
04:14

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

Published on: September 22, 2023

831
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.6K

Area of Science:

  • Gastroenterology
  • Endoscopic Surgery
  • Esophageal Motility Disorders

Background:

  • Per-Oral Endoscopic Myotomy (POEM) is a minimally invasive treatment for achalasia.
  • Unlike laparoscopic Heller myotomy, POEM does not typically include a fundoplication, increasing the risk of post-operative gastroesophageal reflux disease (GERD).

Purpose of the Study:

  • To identify patients experiencing post-POEM reflux using BRAVO pH monitoring and endoscopy.
  • To investigate risk factors for post-POEM reflux and esophagitis to optimize patient selection and management strategies.

Main Methods:

  • Retrospective review of a prospectively collected database of 46 patients who underwent POEM.
  • Analysis of pre- and post-POEM variables, including 48-hour BRAVO pH testing and upper endoscopy.
  • Univariate and multivariate analyses to identify significant risk factors.

Main Results:

  • 41.7% of patients (15/36) showed abnormal esophageal acid exposure on BRAVO pH testing post-POEM.
  • A correlation was found between positive BRAVO results and preoperative esophagitis (p=0.02).
  • Higher preoperative Eckardt scores were significantly associated with post-POEM esophagitis.

Conclusions:

  • Gastroesophageal reflux is a frequent complication following POEM.
  • Objective monitoring (BRAVO pH, endoscopy) is crucial for detecting post-POEM reflux, as many patients are asymptomatic.
  • Preoperative esophagitis and higher Eckardt scores are predictive of post-POEM reflux, warranting vigilant follow-up.