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Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
Published on: April 27, 2018
Germline testing in those at risk of prostate cancer
Peter R Carroll1, John S Witte, J Kellogg Parsons
1Department of Urology and UCSF - Helen Diller Comprehensive Cancer Center, University of California, San Francisco and the Department of Urology, University of California, San Diego, California, USA.
Abstract:
Men with germline mutations in DNA repair genes are at an increased risk of prostate cancer. These germline mutations are commonly seen in conjunction with somatic DNA repair gene mutations in prostate tumors. This indicates that men with a personal or family history of prostate cancer-as well as other cancer syndromes arising from mutations in DNA repair genes-should be considered for genetic testing and counseling.
