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Updated: Jan 5, 2026

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy
Published on: August 20, 2018
The Cumulative Effect of Surface Adsorption and Excluded Volume in 2D and 3D on Protein Fibrillation
1Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Abstract:
A refined mesoscopic model for the cumulative effect of repulsive excluded volume protein-protein interaction and attractive protein-surface interaction upon the properties of a trace protein capable of fiber formation is presented. The model predicts that very small changes in the magnitude of bulk volume occupancy or the strength of protein-surface attraction may result in very large changes in the extent of trace protein fibrillation and the distribution of trace protein between bulk and adsorbed phases.
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