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Antimicrobial resistance of Haemophilus species in patients with chronic bronchitis
Abstract:
Haemophilus influenzae strains resistant to ampicillin have become an important cause of disease in pediatric patients. Because many adults with chronic bronchitis carry Haemophilus organisms in their tracheobronchial tree and because antimicrobial agents are used commonly in these patients, we assessed the prevalence of resistance to ampicillin and other antimicrobial agents in this population. We studied 150 Haemophilus isolates (73 H. influenzae, 69 H. parainfluenzae, 6 H. parahemolyticus, and 2 H. hemolyticus) obtained from 138 patients with chronic bronchitis from January 1978 through March 1979. Ampicillin resistance due to production of beta-lactamase was found in 7 of the 150 isolates (4.7 %)-2 H. influenzae, 4 H. parainfluenzae and 1 H. parahemolyticus. Resistance to tetracycline was found in 9 strains (6 %), but all strains were susceptible to chloramphenicol.
Insights
Ampicillin resistance in Haemophilus strains is a growing concern. This study found ampicillin resistance in 4.7% of Haemophilus isolates from chronic bronchitis patients, highlighting the need for careful antibiotic selection.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Ampicillin-resistant Haemophilus influenzae is a significant pathogen in children.
- Adults with chronic bronchitis often harbor Haemophilus species.
- Antimicrobial use is common in chronic bronchitis management.
Purpose of the Study:
- To determine the prevalence of ampicillin and other antimicrobial resistance in Haemophilus isolates from chronic bronchitis patients.
- To assess the susceptibility patterns of common respiratory pathogens in this population.
Main Methods:
- Analysis of 150 Haemophilus isolates (H. influenzae, H. parainfluenzae, H. parahemolyticus, H. hemolyticus) from 138 chronic bronchitis patients.
- Isolates collected between January 1978 and March 1979.
- Antimicrobial susceptibility testing for ampicillin, tetracycline, and chloramphenicol.
Main Results:
- Ampicillin resistance was detected in 4.7% (7/150) of isolates, attributed to beta-lactamase production.
- Specific resistance observed in 2 H. influenzae, 4 H. parainfluenzae, and 1 H. parahemolyticus.
- Tetracycline resistance was found in 6% (9/150) of strains; all strains remained susceptible to chloramphenicol.
Conclusions:
- A notable prevalence of ampicillin resistance exists in Haemophilus species colonizing the tracheobronchial tree of chronic bronchitis patients.
- Chloramphenicol demonstrated universal susceptibility, suggesting its potential utility.
- Findings underscore the importance of monitoring antimicrobial resistance patterns in respiratory pathogens.