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Alternative dosing regimens for atezolizumab: right dose, wrong frequency.
Daniel A Goldstein1,2,3, Mark J Ratain4
1Tel Aviv University, Tel Aviv, Israel.
Population pharmacokinetics of atezolizumab show trough concentrations exceed the target. Alternative dosing schedules are being explored to improve patient convenience and lower costs.
Area of Science:
- Pharmacology and Oncology
- Immunotherapy Drug Development
Background:
- Population pharmacokinetics (PopPK) analysis of atezolizumab.
- Evaluation of current dosing regimens against therapeutic targets.
Discussion:
- Atezolizumab trough concentrations consistently surpass the 6 µg/ml target.
- This suggests potential for dose optimization.
Key Insights:
- Current atezolizumab dosing achieves concentrations well above the therapeutic threshold.
- Pharmacokinetic data supports exploring less frequent administration schedules.
Outlook:
- Investigating alternative dosing frequencies for atezolizumab.
- Focus on enhancing patient convenience and reducing healthcare expenses.
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