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Updated: Jan 5, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Acquired port-wine stains in six pediatric patients
Michael R Stephens1, Elana Putterman2, Albert C Yan1,2
1Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Background/Objectives:
Port-wine stains, also known as capillary malformations, are due to dermal vascular ectasia and dilation and are most commonly congenital; however, acquired port-wine stains (APWS) developing later in life have been noted in the literature, most commonly in the context of trauma.
Methods/Results:
This case series presents 6 pediatric patients with APWS who first developed lesions between ages 3 and 11 years in the absence of a traumatic or other etiologic trigger.
Conclusions:
The epidemiology, clinical features, and treatment response of these patients are compared to what has been previously described in other cases in the literature.
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