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Related Experiment Video

Updated: Jan 5, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

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Published on: May 10, 2018

New Approach For Simvastatin As An Antibacterial: Synergistic Effect With Bio-Synthesized Silver Nanoparticles

E P Figueiredo¹, J M Ribeiro¹, E K Nishio¹

¹Department of Microbiology, Center of Biological Sciences, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

International Journal of Nanomedicine

|October 22, 2019

Summary

This study shows that combining bio-synthesized silver nanoparticles (AgNP_bio) with simvastatin effectively combats multidrug-resistant bacteria like MRSA. This combination allows for lower AgNP_bio doses while maintaining potent antibacterial activity.

Keywords:

antibacterial metallic nanoparticles multidrug-resistant bacterial statins synergism

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Area of Science:

Nanotechnology
Microbiology
Pharmacology

Background:

Multidrug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), present a significant threat to healthcare.
MRSA is a leading cause of both hospital-acquired and community-associated infections.

Purpose of the Study:

To evaluate the combined antibacterial activity of bio-synthesized silver nanoparticles (AgNP_bio) and simvastatin against multidrug-resistant bacterial strains.
To investigate the synergistic effects of this combination on MRSA and ESBL-producing Escherichia coli.

Main Methods:

Synthesis of silver nanoparticles using Fusarium oxysporum (AgNP_bio).
Determination of minimal inhibitory concentrations (MIC) for simvastatin and AgNP_bio.
Checkerboard assays and time-kill curves to assess synergistic effects.
Scanning electron microscopy to observe bacterial morphological changes.

Main Results:

Simvastatin exhibited MICs between 0.062-0.25 mg mL^-1 against MRSA.
AgNP_bio (77.68± 33.95 nm, zeta potential -34.6 ± 12.7 mV) showed an MIC of 0.212 mg mL^-1 against S. aureus and MRSA.
A synergistic antibacterial effect was observed for the simvastatin-AgNP_bio combination against MRSA.
The combination also showed activity against ESBL-producing Escherichia coli.
Microscopy revealed distinct morphological changes in MRSA treated with AgNP_bio and simvastatin.

Conclusions:

The combination of AgNP_bio and simvastatin offers a promising alternative for controlling bacterial infections.
This synergistic approach allows for reduced dosages of AgNP_bio without compromising antibacterial efficacy.
Further research into this combination could lead to novel therapeutic strategies against resistant bacterial strains.