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Effects of "anorexia" on appetitive and consummatory behavior
D L Wolgin1, I A Oslan, G B Thompson
1Department of Psychology, Florida Atlantic University, Boca Raton 33431.
Behavioral Neuroscience
|April 1, 1988
Summary
Anorexigenic drugs like amphetamine and fenfluramine primarily impact appetitive behaviors (seeking food) rather than consummatory behaviors (eating). This suggests drug effects on food intake are more related to motivation than the act of consumption.
Area of Science:
- Neuroscience
- Behavioral Pharmacology
- Animal Behavior
Background:
- Anorexigenic agents are used to reduce appetite.
- Understanding their effects on different stages of feeding behavior is crucial.
- Distinguishing between appetitive and consummatory behavior is key to understanding drug mechanisms.
Purpose of the Study:
- To investigate how anorexigenic drugs affect appetitive versus consummatory feeding behaviors in rats.
- To determine if drug effects differ based on the method of food delivery (bottle vs. intraoral cannula).
Main Methods:
- Rats were fed sweetened milk via a bottle (appetitive/consummatory) or intraoral cannula (consummatory).
- Effects of amphetamine (AMP) and fenfluramine (FEN) on intake were measured.
- Effects of quinine hydrochloride (QHCl) on intake and AMP in a conditioned aversion paradigm were assessed.
Main Results:
- Amphetamine and fenfluramine suppressed intake more in bottle-fed rats than cannula-fed rats.
- Quinine hydrochloride also showed greater suppression in bottle-fed rats.
- Amphetamine induced greater aversion in bottle-fed rats during conditioned taste aversion.
Conclusions:
- Anorexigenic drugs appear to exert a stronger influence on appetitive aspects of feeding behavior.
- Findings suggest that drug-induced suppression of food intake is more related to the motivation to seek food than the act of eating itself.