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Updated: Jan 5, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Enantioselective Synthesis of Hydrothiazole Derivatives via an Isocyanide-Based Multicomponent Reaction
Qian Xiong1, Gonglin Li1, Shunxi Dong1
1Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry , Sichuan University , Chengdu 610064 , China.
Abstract:
Catalytic asymmetric synthesis of hydrothiazole derivatives was developed via a well-organized formal [2 + 1 + 2] cycloaddition reaction triggered by asymmetric addition of isocyanide to alkylidene malonate. Various chiral hydrothiazole derivatives were readily provided in good yield with high enantioselectivity (up to 98% yield, 98.5:1.5 er) utilizing a chiral Mg(OTf)2/N,N'-dioxide complex as the catalyst under mild conditions. Based on the experimental studies and the structure of the catalyst, a possible catalytic cycle was proposed to elucidate the reaction process and activation mode.
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