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Painful interactions: Microbial compounds and visceral pain
I A M van Thiel1, S Botschuijver1, W J de Jonge1
1Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, location AMC, Meibergdreef 69, 1105 BK Amsterdam, the Netherlands.
Biochimica Et Biophysica Acta. Molecular Basis of Disease
|October 22, 2019
Summary
Microbial compounds interacting with immune and nervous systems can trigger visceral pain, a common symptom in conditions like irritable bowel syndrome. Understanding these interactions is key to managing abdominal discomfort.
Area of Science:
- Immunology
- Neuroscience
- Microbiology
Background:
- Visceral pain, marked by abdominal discomfort, is prevalent in conditions such as irritable bowel syndrome, vulvodynia, and interstitial cystitis.
- Organs involved in visceral pain are exposed to microbes, necessitating immune and nervous system cooperation for homeostasis and infection prevention.
Purpose of the Study:
- To review microbial compounds and their receptors implicated in the development of visceral pain.
- To explore the interplay between the immune and nervous systems in response to microbial stimuli in visceral organs.
Main Methods:
- Literature review of studies investigating microbial components and their roles in visceral pain.
- Analysis of receptor-mediated signaling pathways activated by microbial products in immune and nervous cells.
Main Results:
- Microbial recognition by immune and nervous system receptors can initiate inflammatory responses.
- These responses, triggered by microbial components, are linked to the pathogenesis of visceral pain.
Conclusions:
- Microbial factors and their interactions with host receptors are significant contributors to visceral pain.
- Targeting these microbial-host interactions presents a potential therapeutic strategy for visceral pain management.
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