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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

462
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Related Experiment Video

Updated: Jan 5, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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An association between right ventricular dysfunction and sudden cardiac death.

Summit Pandat1, Takafumi Nagaura1, Sandeep G Nair1

  • 1Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Heart Rhythm
|October 22, 2019
PubMed
Summary

Right ventricular dysfunction significantly increases sudden cardiac death risk, independent of left ventricular ejection fraction. Combining both RV and LV dysfunction further elevates this risk, offering new insights for risk stratification.

Keywords:
Cardiac arrestEchocardiogramRight ventricleRisk predictionSudden death

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Related Experiment Videos

Last Updated: Jan 5, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

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Area of Science:

  • Cardiology
  • Echocardiography
  • Sudden Cardiac Death Research

Background:

  • Left ventricular ejection fraction (LVEF) <35% is a less effective predictor of sudden cardiac death (SCD).
  • Novel markers are needed for improved SCD risk stratification.
  • Right ventricular (RV) abnormalities are linked to SCD in conditions like COPD and sleep apnea.

Purpose of the Study:

  • To determine if RV abnormalities are associated with SCD.
  • To assess RV abnormalities independently of LVEF and other patient factors.

Main Methods:

  • A prospective, community-based study of SCD cases and controls.
  • Analysis of digital echocardiograms to assess RV basal diameter, RV end-diastolic area, and RV fractional area change (RVFAC).
  • Multivariate analysis to evaluate associations with SCD.

Main Results:

  • RV fractional area change (RVFAC) was significantly associated with SCD (OR 1.14 per 5% decrease, P=.01).
  • RV dysfunction (RVFAC ≤35%) combined with low LVEF (≤35%) significantly increased SCD risk.
  • Individuals with both left and right ventricular dysfunction had 3x higher odds of SCD (OR 3.19, P=.01).

Conclusions:

  • RV dysfunction is an independent predictor of SCD, even when LVEF is normal.
  • Combined RV and left ventricular dysfunction have additive effects on SCD risk.
  • RV abnormalities represent a crucial, underutilized marker for SCD risk stratification.