Normal Patterns and Pitfalls of FDG Uptake in the Head and Neck

In order to avoid misdiagnoses, medical imagers should be familiar with the normal patterns and distribution of fluorodeoxyglucose (FDG) activity within the head and neck, as well as the pathophysiology and imaging-findings of common diagnostic pitfalls related to incidental FDG-avid lesions. The purpose of this article is to provide an image-rich review of the normal patterns of FDG uptake in the head and neck, help differentiate benign from malignant incidentally found FDG-avid foci, and detail important "don't miss" hypometabolic head and neck lesions on positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging.