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High-throughput Screening of Recalcitrance Variations in Lignocellulosic Biomass: Total Lignin, Lignin Monomers, and Enzymatic Sugar Release
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Genetically encoded biosensors for lignocellulose valorization.

Guadalupe Alvarez-Gonzalez1, Neil Dixon1

  • 1Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, UK.

Biotechnology for Biofuels
|October 23, 2019
PubMed
Summary
This summary is machine-generated.

Developing cell factories using synthetic biology and metabolic engineering can convert lignin into valuable chemicals. Genetically encoded biosensors accelerate this process, enabling a sustainable bioeconomy and efficient biorefineries.

Keywords:
BiorefineryGenetically encoded biosensorsLignocellulose valorizationSustainable chemical production

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Area of Science:

  • Biotechnology and Synthetic Biology
  • Chemical Engineering
  • Sustainable Chemistry

Background:

  • Modern society relies heavily on finite fossil fuels for chemicals and energy.
  • Transitioning to renewable feedstocks is crucial for a low-carbon bioeconomy.
  • Lignin, a biomass component, holds potential as a renewable aromatic source if effectively utilized.

Purpose of the Study:

  • To explore the use of synthetic biology and metabolic engineering for lignin valorization.
  • To address bottlenecks in pathway design and optimization for bioproduction.
  • To develop and apply genetically encoded biosensors for high-throughput screening and dynamic pathway regulation.

Main Methods:

  • Employing synthetic biology and metabolic engineering to design novel biosynthetic pathways.
  • Utilizing genetically encoded biosensors for high-throughput screening of genetic variants.
  • Engineering cell factories for the degradation, conversion, and valorization of lignin.

Main Results:

  • Demonstrated the potential of cell factories for producing valuable chemicals from lignin.
  • Showcased biosensors as effective tools for overcoming screening limitations and metabolic burden.
  • Facilitated high-throughput phenotypic read-outs and dynamic pathway regulation.

Conclusions:

  • Synthetic biology and metabolic engineering, aided by biosensors, are key to unlocking lignin's potential.
  • This approach enables the development of efficient biocatalytic processes for lignin valorization.
  • Paves the way for a sustainable and economically viable biorefinery.