Related Experiment Video
Updated: Jan 5, 2026
07:30
Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
4.2K
Is obesity a contraindication for kidney donation?
Lilli Schussler1, Prerna Khetan1, Matthew Peacock1
1Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Surgical Endoscopy
|October 23, 2019
Summary
Living kidney donors with obesity are safe. This study found no significant differences in kidney function or complications after surgery for obese versus non-obese donors.
Area of Science:
- Nephrology
- Transplant Surgery
- Obesity Medicine
Background:
- Expanding the donor pool is crucial for kidney transplantation.
- Obesity is a growing concern, necessitating evaluation of obese individuals as potential living kidney donors.
Purpose of the Study:
- To assess the safety and impact of obesity on kidney donors undergoing nephrectomy.
- To evaluate postoperative renal function and complication rates in living kidney donors with obesity.
Main Methods:
- Single-center retrospective analysis of laparoscopic donor nephrectomy.
- Comparison of outcomes between kidney donors with obesity (BMI 30-35 kg/m²) and those without.
- Analysis of glomerular filtration rate (GFR), creatinine levels, and complication rates at various postoperative intervals.
Main Results:
- No significant differences in demographics or comorbidities between obese and non-obese donors.
- Obese donors had a significantly longer operative time (p=0.03).
- Postoperative creatinine and GFR levels were comparable between groups at 6, 12, and 24 months.
Conclusions:
- Carefully screened living kidney donors with obesity demonstrate safe postoperative renal function.
- Obesity does not appear to negatively impact long-term kidney function in living donors.
- Laparoscopic donor nephrectomy is a viable option for carefully selected obese individuals.
Related Concept Videos
01:28Kidney Transplant I: Introduction
296
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
296
01:26Kidney Transplant II: Surgical Procedure
267
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
267
01:21Drug Dosing: Obese Patients
184
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
184
01:21External Anatomy of the Kidney
3.2K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.2K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
144
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
144
01:16Kidney Transplant III: Nursing Management
284
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
284