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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Visible-Light-Induced Deaminative Thioesterification of Amino Acid Derived Katritzky Salts via Electron
Mingcheng Yang1, Tianpeng Cao1, Tianxiao Xu1
1Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry , Fuzhou University , 2 Xueyuan Road , Fuzhou 350116 , P.R. China.
Abstract:
A visible-light-mediated deaminative thioesterification of amino acid derived Katritzky salts with thiobenzoic acid has been developed, which provides a novel synthetic method for the synthesis of α-mercapto acid derivatives under mild conditions. This photoredox catalyst-free generation of alkyl radicals via C-N bond cleavage is enabled by the formation of an electron-donor-acceptor (EDA) complex between the Katritzky salt and thiobenzoic acid anion, which represents a new entry for EDA complex chemistry.
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