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Cohort profile: the Biology, Affect, Stress, Imaging and Cognition (BASIC) study on perinatal depression in a

Cathrine Axfors1, Emma Bränn1, Hanna E Henriksson1

  • 1Women's and Children's Health, Uppsala University, Uppsala, Sweden.

BMJ Open
|October 24, 2019
PubMed

Insights

The Biology, Affect, Stress, Imaging and Cognition (BASIC) study investigates perinatal depression (PND) predictors using biopsychosocial factors. Findings aid in early PND detection and management strategies.

Area of Science:

  • Perinatal mental health research
  • Reproductive psychiatry
  • Biopsychosocial factors in maternal health

Background:

  • Perinatal depression (PND) affects maternal well-being and infant development.
  • Understanding the complex etiology of PND is crucial for effective interventions.
  • The Biology, Affect, Stress, Imaging and Cognition (BASIC) cohort provides a unique resource for studying PND.

Purpose of the Study:

  • To investigate the biopsychosocial etiological processes of perinatal depression (PND).
  • To identify predictors of PND for improved early detection.
  • To leverage a large, prospective population-based cohort for comprehensive analysis.

Main Methods:

  • Prospective, population-based cohort study (BASIC) enrolling 5492 women across 6478 pregnancies.
  • Data collection includes internet-based surveys, biological samples (blood, placenta, microbiota), and specialized tests (cognitive, emotional, HRV, bioimpedance).
  • Longitudinal follow-up from early pregnancy (gestational week 16-18) through 1 year postpartum, with ongoing child follow-up (U-BIRTH).

Main Results:

  • Subprojects have identified various psychological, obstetric, hypothalamic-pituitary-adrenal axis, and immune system correlates of PND.
  • Preliminary findings highlight multifactorial origins of PND.
  • Ongoing analysis of comprehensive data is expected to yield further insights.

Conclusions:

  • The BASIC cohort is instrumental in elucidating the complex origins of perinatal depression.
  • Identifying early predictors through biopsychosocial assessment can enhance PND detection.
  • Continued research and collaboration are vital for advancing perinatal mental health care.
Abstract

Keywords:
cohort studymother-child relationspituitary-adrenal systempostpartum depressionpregnancypsychoneuroimmunology

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