Serum Stem Cell Factor Level Predicts Decline in Kidney Function in Healthy Aging Adults
1Mr. Weiguang Zhang, Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Disease, National Clinic Research Center for Kidney Diseases, A28 Fuxing Road, Beijing 100853, China; Tel +86 15811088843;
The Journal of Nutrition, Health & Aging
|October 24, 2019
Summary
Serum Stem Cell Factor (SCF) levels are a reliable biomarker for kidney aging. Higher SCF levels correlate with declining kidney function (eGFR) in aging individuals, aiding in predicting renal function changes.
Area of Science:
- Nephrology
- Gerontology
- Biomarker Discovery
Background:
- Stem Cell Factor (SCF) is implicated in organ reconstruction and fibrosis in kidney disease.
- The role of SCF in the physiological process of kidney aging remains largely unexplored.
Purpose of the Study:
- To investigate the association between serum SCF levels and kidney function during aging.
- To identify novel biomarkers for kidney aging.
Main Methods:
- Serum SCF levels, estimated glomerular filtration rate (eGFR), and other biological parameters were measured in 892 Chinese Han subjects.
- Multiple linear regression analysis was employed to identify predictors of renal function decline.
Main Results:
- Age, SCF level, and 25% maximum expiratory flow (25% MEF) were significant predictors of renal function decline.
- The relationship was quantified as: eGFR = 154.486 - (0.846 × age) - (0.011 × SCF level).
- No significant gender-based differences were observed in the effect of SCF on kidney aging.
Conclusions:
- Serum SCF level is a valuable biomarker for assessing renal aging.
- SCF levels can potentially predict age-related changes in eGFR.
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