The Toxicology Investigators Consortium Case Registry-the 2018 Annual Report

Area of Science:

• Medical Toxicology
• Clinical Data Registries
• Public Health Surveillance

Background:

• The American College of Medical Toxicology established the Toxicology Investigators Consortium (ToxIC) Registry in 2010.
• The Registry systematically collects data from medical toxicology consultations nationwide.
• This report details the 2018 data, representing the ninth annual summary of Registry activity.

Purpose of the Study:

• To summarize the 2018 data and activity from the ToxIC Registry.
• To analyze trends in demographics, exposure characteristics, and outcomes.
• To report on specific sub-analyses, including elderly patients, addiction consultations, and bupropion-induced seizures.

Main Methods:

• Data extracted from the ToxIC database for cases entered between January 1 and December 31, 2018.
• Aggregation of detailed case information including demographics, exposure agents, clinical signs, treatments, and mortality.
• Sub-analyses performed on specific patient populations and exposure scenarios.

Main Results:

• 7,043 new cases were added in 2018.
• Non-opioid analgesics, antidepressants, and opioids were the most common agent classes; acetaminophen was the most frequent agent.
• 106 fatalities (1.5%) were recorded, with trends remaining similar to previous years.

Conclusions:

• The ToxIC Registry continues to be a valuable resource for understanding medical toxicology consultations.
• Key trends in patient demographics and exposure characteristics are consistent with prior reports.
• The launch of the ToxIC Qualified Clinical Data Registry (TQCDR) marks a significant advancement in data utilization.