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Multifunctional neuron-specific enolase: its role in lung diseases
Cai-Ming Xu1,2, Ya-Lan Luo1, Shuai Li3
1Department of General Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning, China; Institute (College) of Intergrative Medicine, Dalian Medical University, Dalian 116044, Liaoning, China.
Bioscience Reports
|October 24, 2019
Summary
Neuron-specific enolase (NSE) is a multifunctional protein found in neurons and neuroendocrine cells. This article explores NSE's role and diagnostic potential in various lung diseases.
Area of Science:
- Biochemistry
- Cell Biology
- Pathology
Background:
- Neuron-specific enolase (NSE), also known as gamma (γ) enolase or enolase-2 (Eno2), is a key glycolytic enzyme.
- NSE is primarily found in the cytoplasm of neurons and neuroendocrine cells, including those in the amine precursor uptake and decarboxylation (APUD) lineage.
- Altered NSE expression and localization are linked to various pathologies, including infections, inflammation, autoimmune diseases, and cancer.
Purpose of the Study:
- To discuss the multifaceted role of Neuron-specific enolase (NSE).
- To investigate the diagnostic potential of NSE in the context of lung diseases.
Main Methods:
- Literature review and synthesis of existing research on NSE.
- Analysis of NSE expression patterns and functions in cellular and disease contexts.
Main Results:
- NSE plays a critical role beyond glycolysis, acting as a multifunctional protein.
- Changes in NSE levels and location are significant indicators in disease states.
- Specific associations between NSE and certain lung pathologies are highlighted.
Conclusions:
- Neuron-specific enolase (NSE) is a crucial biomarker with diagnostic implications for lung diseases.
- Understanding NSE's diverse functions can enhance diagnostic strategies for pulmonary conditions.
Keywords:
Chronic obstructive pulmonary diseaseEnolaseNeuron-specific enolasePulmonary alveolar proteinosisSolitary pulmonary nodulesMore Related Videos
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