Related Experiment Videos
Cystic fibrosis in Norway
1Dept. of Paediatrics, Aker Hospital, Oslo, Norway.
Insights
This study presents data on 165 Norwegian cystic fibrosis (CF) patients, noting a high mean age at diagnosis and a male predominance in younger groups. Pseudomonas aeruginosa infections are notably infrequent in this CF cohort.
Area of Science:
- Pediatrics
- Pulmonology
- Medical Genetics
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs, primarily the lungs.
- Understanding CF patient demographics and infection patterns is crucial for disease management.
- Previous research highlights variations in CF presentation and complications across different populations.
Purpose of the Study:
- To describe the clinical characteristics of a Norwegian cystic fibrosis cohort.
- To analyze the age at diagnosis, sex distribution, and Pseudomonas aeruginosa infection rates in Norwegian CF patients.
Main Methods:
- Retrospective analysis of a registry-based cohort of 165 Norwegian patients with cystic fibrosis.
- Data collection through yearly questionnaires.
- Analysis of demographic data, age at diagnosis, and respiratory infection status.
Main Results:
- The cohort comprised 165 Norwegian patients with CF, with 149 currently alive.
- The mean age at diagnosis was notably high, even with infant screening.
- A significant male predominance was observed in younger CF patients, diminishing in adults.
- A strikingly low incidence and prevalence of chronic Pseudomonas aeruginosa respiratory infections were recorded.
Conclusions:
- The Norwegian CF patient cohort exhibits distinct demographic features, including a high age at diagnosis and sex-specific differences in younger patients.
- The low prevalence of Pseudomonas aeruginosa infections in this cohort warrants further investigation to understand underlying factors.
- These findings contribute to the understanding of geographical and population-specific variations in cystic fibrosis.
Abstract:
A material of 165 Norwegian patients with cystic fibrosis (CF) is presented. 149 patients are still alive. The material is based on a central registry for CF with information gathered from yearly distribution of questionnaires. The mean age at diagnosis is high in Norway, even when screened infants are included. A further characteristic of the material is the striking male preponderance in the younger age groups, whereas there is no sex difference in the group of adult CF patients. Very striking is the low incidence and prevalence of chronic respiratory tract infections caused by Pseudomonas aeruginosa; the reason for this is unexplained.