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Major depression subtypes are differentially associated with migraine subtype, prevalence and severity
Claudia Pisanu1,2, Emma Lundin1, Martin Preisig3
1Department of Neuroscience, University of Uppsala, Uppsala, Sweden.
Cephalalgia : an International Journal of Headache
|October 25, 2019
Summary
Melancholic depression is linked to a higher frequency of migraine with and without aura. This finding highlights specific connections between subtypes of major depressive disorder and migraine, warranting further research into shared mechanisms.
Area of Science:
- Neuroscience
- Psychiatry
- Epidemiology
Background:
- Migraine and major depressive disorder (MDD) frequently co-occur.
- Understanding the specific links between MDD subtypes and migraine is limited.
Purpose of the Study:
- To investigate lifetime associations between MDD subtypes (atypical, melancholic, combined, unspecified) and migraine (with/without aura).
- To examine the relationship between MDD subtypes and migraine severity.
Main Methods:
- Cross-sectional study of 446 migraine patients and 2511 controls from the CoLaus/PsyCoLaus study.
- Binary logistic or linear regression analyses were used to test associations.
Main Results:
- Melancholic, combined, and unspecified MDD were linked to increased migraine with aura frequency.
- Melancholic MDD was associated with increased migraine without aura frequency.
- Combined MDD correlated with higher migraine frequency irrespective of aura presence.
Conclusions:
- Melancholic MDD, unlike atypical MDD, shows a significant association with migraine and its subtypes.
- Further research into shared pathophysiological mechanisms between melancholic depression and migraine is recommended.
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