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Updated: Dec 12, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Tasquinimod targets suppressive myeloid cells in the tumor microenvironment
Li Shen1, Roberto Pili1,2
1Genitourinary Program, Roswell Park Cancer Institute, Buffalo, NY, USA.
Abstract:
Infiltrating myeloid derived suppressor cells and tumor-associated macrophages (TAMs) are important components of the immunosuppressive tumor microenvironment. We recently reported that tasquinimod, which binds to S100A9, impairs both infiltration and function of these cells. Here we discuss the underlying mechanisms responsible for targeting multiple suppressive populations and the modulation of the tumor microenvironment.
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