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Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
Sara Verdura1,2, Elisabet Cuyàs1,2, Begoña Martin-Castillo3
1Program Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Spain.
Abstract:
The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.
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