Progress in 3D bioprinting technology for tissue/organ regenerative engineering.

Area of Science:

• Regenerative Medicine
• Tissue Engineering
• Advanced Materials Science
• Stem Cell Science
• Developmental Biology
• Physics
• Clinical Translation

Background:

• Global organ shortage and donor scarcity necessitate alternatives to allograft tissues.
• Regenerative medicine and tissue engineering aim to create artificial tissues and organs for transplantation.
• Regenerative Engineering integrates multiple scientific disciplines for tissue and organ regeneration.

Purpose of the Study:

• To review advancements in 3D bioprinting technologies for tissue and organ regeneration.
• To examine bioprinting process parameters, bioinks, and biomaterials.
• To highlight applications, challenges, and future perspectives of 3D bioprinting.

Main Methods:

• Review of recent progress in various bioprinting technologies.
• Examination of process parameters influencing bioprinting.
• Analysis of bioink-biomaterial properties and their impact.

Main Results:

• 3D bioprinting enables precise positioning of cells and ECM for multi-cellular tissue fabrication.
• Successful bioprinting of various tissues including skin, cardiac, bone, cartilage, liver, lung, neural, and pancreatic.
• Exploration of applications in cancer research, drug testing, and organ-on-a-chip models.

Conclusions:

• 3D bioprinting is a key technology within Regenerative Engineering for creating complex tissues.
• Significant progress has been made in bioprinting diverse tissue types and in related applications.
• Challenges remain in clinical translation, but future perspectives for bioprinting are promising.