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Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases

Krisnawan Andy Pradana1,2, Michael Anekson Widjaya1, Mariana Wahjudi1

  • 1Faculty of Biotechnology, University of Surabaya, Surabaya City, Indonesia.

Immunological Investigations
|October 26, 2019
PubMed

In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn's disease, rheumatoid arthritis, Graves' disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles.

Keywords:
AlleleHLAIndonesiaglobal disease

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