Stepping into the Next Dimension of Biomaterial Design
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Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels
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1Chemical Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA.
Trends in Biotechnology
|October 26, 2019
Abstract:
Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.
