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Role of mTOR Signaling in Female Reproduction

Zaixin Guo1, Qi Yu1

  • 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Frontiers in Endocrinology
|October 26, 2019
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates female reproduction. This review explores mTOR

Area of Science:

  • Reproductive biology and molecular medicine.

Background:

  • The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, metabolism, and autophagy.
  • mTOR signaling is implicated in various human diseases, including cancer, neurodegeneration, and aging.

Purpose of the Study:

  • To summarize recent findings on the role of mTOR in female reproduction under physiological and pathological conditions.
  • To evaluate the therapeutic potential of modulating mTOR for reproductive disorders.

Main Methods:

  • Review of current scientific literature on mTOR and female reproduction.
  • Analysis of studies investigating mTOR's mechanisms in reproductive health and disease.

Main Results:

  • mTOR plays a critical role in various aspects of female reproductive function.
  • Dysregulation of mTOR is associated with conditions such as premature ovarian failure, polycystic ovary syndrome, and endometriosis.

Conclusions:

  • Targeting the mTOR pathway presents a potential therapeutic strategy for managing female reproductive diseases.
  • Further research is needed to fully elucidate mTOR's complex role and optimize therapeutic interventions.
Keywords:
endometriosisfollicular developmentgonadotoxicitymTOR signalingoocyte maturationovulationpolycystic ovarian syndrome (PCOS)steroidogenesis

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