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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer

Xiaoming Zhong1, Bin Chen2, Min Liu2

  • 1Jiangxi Province Tumor Hospital, Nanchang, China.

Molecular Therapy Oncolytics
|October 26, 2019
PubMed

Insights

The CARD9 protein is crucial for anti-fungal immunity and also plays a vital role in colitis-associated colorectal cancer (CAC) development. This review explores CARD9

Area of Science:

  • Immunology
  • Oncology
  • Gastroenterology

Background:

  • The adaptor protein CARD9 is essential for anti-fungal immunity by linking fungal detection to NF-κB activation.
  • Emerging evidence highlights distinct, critical roles for CARD9 in the pathogenesis of colitis-associated colorectal cancer (CAC).

Purpose of the Study:

  • To review and synthesize current knowledge on CARD9's functions in CAC.
  • To discuss the potential mechanisms by which CARD9 contributes to colorectal cancer development in the context of colitis.

Main Methods:

  • Literature review of recent studies on CARD9 in immunity and cancer.
  • Analysis of CARD9's signaling pathways in relation to CAC.
  • Discussion of potential therapeutic targets related to CARD9 in CAC.

Main Results:

  • CARD9 mediates inflammatory responses relevant to both fungal infections and CAC.
  • CARD9 signaling pathways are implicated in promoting tumor initiation and progression in CAC.
  • Understanding CARD9's dual role offers insights into novel therapeutic strategies for CAC.

Conclusions:

  • CARD9 is a key regulator in both anti-fungal immunity and the development of CAC.
  • Further research into CARD9's mechanisms in CAC is warranted for therapeutic development.
  • Targeting CARD9 may offer a promising approach for treating colitis-associated colorectal cancer.

Keywords:
CARD9IL-22STAT3colitis-associated cancerinflammasome activationmyeloid-derived suppressor cells

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