[Research progress on tranexamic acid in traumatic orthopedic surgery]

Area of Science:

• Orthopedic Surgery
• Trauma Care
• Pharmacology

Background:

• Traumatic orthopedic surgery often involves significant blood loss.
• Tranexamic acid (TXA) is an antifibrinolytic agent with potential to reduce surgical bleeding.
• Recent years have seen increased interest in TXA's application in orthopedic trauma.

Purpose of the Study:

• To review and summarize current research on tranexamic acid (TXA) in traumatic orthopedic surgery.
• To evaluate the efficacy and safety of different TXA regimens, doses, and administration routes.

Main Methods:

• Comprehensive review of domestic and international literature.
• Analysis of studies on TXA in various traumatic orthopedic procedures.
• Comparison of TXA's effectiveness and safety across different surgical contexts.

Main Results:

• TXA application in traumatic orthopedic surgery has increased.
• Intravenous or topical TXA significantly reduced blood loss and transfusion needs in hip fracture surgery.
• The efficacy of TXA in pelvic and acetabular fracture surgeries remains unclear, with no significant increase in thromboembolic events observed.

Conclusions:

• TXA demonstrates efficacy in reducing blood loss for hip fracture surgery.
• Further research is necessary to establish the definitive efficacy and safety of TXA in other traumatic orthopedic surgeries.
• More studies are required to confirm the benefits and risks of TXA in complex orthopedic trauma cases.